瀏覽人氣：431

蔡福明 研究員

最高學歷：國防醫學院生命科學研究所博士

研究領域：維甲酸誘導基因抗癌機轉之研究、中草藥萃取物之免疫調節機轉之探討

分機：5793

電子信箱：xd109061@tzuchi.com.tw

https://orcid.org/0000-0002-4563-0458

  • 維甲酸誘導基因抗癌機轉之研究。
  • 中草藥萃取物調控血小板活性及細胞生長的影響。

代表著作：

  1. Wang CH, Lu TJ, Wang LK, Wu CC, Chen ML, Kuo CY, Shyu RY, Tsai FM*. (2021). Tazarotene‐induced gene 1 interacts with Polo‐like kinase 2 and inhibits cell proliferation in HCT116colorectal cancer cells. Cell Biology International. 45:2347–2356.
  2. Wang CH, Wang LK, Wu CC, Chen ML, Kuo CY, Shyu RY*, Tsai FM*. (2020). Cathepsin V mediates the tazarotene-induced gene 1-induced reduction in invasion in colorectal cancer cells. Cell Biochemistry and Biophysics. 78: 483–494. (*Equal Contribution).
  3. Wang CH, Wang LK, Wu CC, Chen ML, Lee MC, Lin YY, Tsai FM*. (2019). The ribosomal protein RPLP0 mediates PLAAT4-induced cell cycle arrest and cell apoptosis. Cell Biochemistry and Biophysics. 77(3):253–260.
  4. Wang CH, Shyu RY, Wu CC, Chen ML, Lee MC, Lin YY, Wang LK, Jiang SY, Tsai FM*. (2018). Tazarotene-induced gene 1 interacts with DNAJC8 and regulates glycolysis in cervical cancer cells. Molecules and Cells. 41(6): 562-574.
  5. Shyu RY, Wang CH, Wu CC, Chen ML, Lee MC, Wang LK, Jiang SY*, Tsai FM*. (2016). Tazarotene-induced gene 1 enhanced cervical cell autophagy through transmembrane protein 192. Molecules and Cells. 39(12): 877-887.

參考著作：

  1. Lu PH†, Liao TH†, Chen YH, Hsu YL, Kuo CY, Chan CC, Wang LK, Chern CY*, Tsai, FM*. (2022). Coumarin derivatives Inhibit ADP-Induced platelet Activation and aggregation. Molecules, 27, 4054.
  2. Liu CJ, Wang LK, Kuo CY, Chen ML, Tzeng IS, Tsai FM*. (2021). Tournefortia sarmentosa inhibits the hydrogen peroxide-induced death of H9c2 cardiomyocytes. Evidence-Based Complementary and Alternative Medicine. 2021. Article ID 8219141.
  3. Lu PH, Kuo CY, Chan CC, Wang LK, Chen ML, Tzeng IS, Tsai FM*. (2021). Safflower extract inhibits ADP-induced human platelet aggregation. Plants. 2021, 10, 1192.
  4. Wang CC, Wang LK, Chen ML, Kuo CY, Tsai FM*, Wang CH*. (2020). Triterpenes in the Ethanol Extract of Poria cocos Induce Dermal Papilla Cell Proliferation. International Journal of Pharmacology. 16: 1-9. (*Equal Contribution)
  5. Tsai FM, Wang LK, Chen ML, Lee MC, Lin YY, Wang CH*. (2019). Induction of cell proliferation and cell death in human follicle dermal papilla cells by zinc chloride. Indian Journal of Pharmaceutical Sciences. 81(4):781-785.

  6. Tsai FM, Li CH, Wang LK, Chen ML, Lee MC, Lin YY, Wang CH*. (2019). Extracellular signal-regulated kinase mediates ebastine-induced human follicle dermal papilla cell proliferation. BioMed Research International. 2019: Article ID 6360503.

  • 癌症及細胞學研究團隊。主持人：高偉堯醫師。
    • 小分子核糖核酸(microRNA)可經由轉錄及轉譯作用調節標的蛋白質的表現，而且也可釋出細胞外當作生物標記。團隊之成立，除了期望找出可用的小分子核糖核酸作為Cetuximab或其它用藥的治療指標外，亦探討小分子核糖核酸的作用機轉。

  • 藥物對毛髮生長的影響。主持人：王淳樺醫師、呂秉勳醫師。
    • 角質細胞與毛囊毛乳頭细胞主要控制毛髮的生長。找尋合適藥物促進上述細胞的生長可改善因先天或藥物(如化療藥物)造成落髮的情形。目前我們已找尋到幾個侯選中藥或單方可促進毛囊毛乳頭细胞的生長，且作用機轉亦正詳細探討中。