111年9月1日（四）12：30於3樓合心會議室舉辦「研究發想會」，由國立陽明交通大學藥學系 蘇溶真 助理教授

主講「以新穎 AMPK 活化劑抑製有氧糖酵解做為肝細胞癌治療方向」，歡迎有興趣的同仁前往聆聽。

本次講座摘要：

5′ AMP-activated protein kinase (AMPK) is one of the central regulators of cellular metabolism that has been linked to the regulation of tumor progression and the metabolic reprogramming in hepatocellular carcinoma (HCC). In our study, we developed a novel allosteric AMPK activator, SCT-1015. Under the treatment of SCT-1015, the activated AMPK negatively regulated transcription factor HIF1α through both inducing HIF1α degradation (ERK/PHD-dependent proline hydroxylation on HIF1α) and suppressing HIF1α synthesis (mTORC1 signaling pathway). As a result of the reduced protein abundance of HIF1α, the transcription of the enzymes regulating glycolysis and oxidative phosphorylation was decreased. Such downregulation led to reduced glycolysis and increased oxidative phosphorylation thus attenuating the Warburg phenotype and eliciting an anti-HCC effect in vitro and in vivo. Our results demonstrated the role of AMPK mediated pathway in HCC metabolic reprogramming, and provided the therapeutic possibility through AMPK activation by a newly developed small molecule, SCT-1015