瀏覽人氣：681

鄧明生 助理研究員

最高學歷：台北醫學大學醫學科學研究所博士

研究領域：分子遺傳學、基因體學

分機：5790

電子信箱：vincent@tzuchi.com.tw

https://orcid.org/0000-0003-4140-5699

高密度脂蛋白與血中生物標記於心血管疾病之遺傳關聯性及功能性研究探討

科技部專題研究計畫：

108年度 【全基因組關聯性與斑馬魚功能性基因體之整合性研究：作用於遺傳基因位點與高密度脂蛋白膽固醇和三酸甘油酯之抑制效應的機制探討】

         計畫編號： MOST 108-2314-B-303-012     

         執行期限： 108/08/01 ～ 109/07/31

109年度 【 全基因組關聯性與斑馬魚功能性基因體之整合性研究：作用於遺傳基因位點與高密度脂蛋白膽固醇和三酸甘油酯之抑制效應的機制探討(II) 】

         計畫編號：MOST 109-2314-B-303 -021 -MY2    

         執行期限： 109/08/01 ～ 111/07/31

111年度 【探討台灣健康族群中高密度脂蛋的動態結構以及多效功能之全基因組關聯性和功能性基因體學之整合研究：應用並轉譯至周邊動脈疾病】

         計畫編號：MOST 111-2314-B-303-002 –

         執行期限： 111/08/01 ～ 112/07/31

台北慈濟醫院：

心臟內科: 柯毓麟醫師、黃玄禮醫師、周星輝醫師

新陳代謝科: 廖瑜皇醫師、余麗嬌醫師

神經外科: 徐賢達醫師

院外合作機構:

文化大學生命科學系: 吳賜猛教授

臺灣大學生化所: 管永恕副教授

  1. Teng MS, Yeh KH, Hsu LA, Chou HH, Er LK, Wu S, Ko YL. Differential Effects of ABCG5/G8 Gene Region Variants on Lipid Profile, Blood Pressure Status, and Gallstone Disease History in Taiwan.Genes (Basel). 2023 Mar 20;14(3):754.
  2. Chen HH, Hsu HT, Liao MH, Teng MS*. Effects of Sex and Obesity on LEP Variant and Leptin Level Associations in Intervertebral Disc Degeneration. Int J Mol Sci. 2022 Oct 14;23(20):12275.
  3. Hsu LA, Teng MS, Wu S, Chou HH, Ko YL. Common and Rare PCSK9 Variants Associated with Low-Density Lipoprotein Cholesterol Levels and the Risk of Diabetes Mellitus: A Mendelian Randomization Study. Int J Mol Sci. 2022 Sep 8;23(18):10418.
  4. Yeh KH, Wan HL, Teng MS, Chou HH, Hsu LA, Ko YL.Genetic Variants at the APOE Locus Predict Cardiometabolic Traits and Metabolic Syndrome: A Taiwan Biobank Study. Genes (Basel). 2022 Jul 29;13(8):1366.
  5. Wu S, Hsu LA, Teng MS, Chou HH, Ko YL. Differential Genetic and Epigenetic Effects of the KLF14 Gene on Body Shape Indices and Metabolic Traits. Int J Mol Sci. 2022 Apr 9;23(8):4165.
  6. Jang SJ, Tuan WL, Hsu LA, Er LK, Teng MS, Wu S, Ko YL. Pleiotropic Effects of APOB Variants on Lipid Profiles, Metabolic Syndrome, and the Risk of Diabetes Mellitus. Int J Mol Sci. 2022 Nov 29;23(23):14963.
  7. Yeh KH, Hsu LA, Teng MS, Wu S, Chou HH, Ko YL. Pleiotropic Effects of Common and Rare GCKR Exonic Mutations on Cardiometabolic Traits. Genes (Basel). 2022 Mar 10;13(3):491.
  8. Chou HH, Hsu LA, Juang JJ, Chiang FT, Teng MS, Wu S, Ko YL. Synergistic Effects of Weighted Genetic Risk Scores and Resistin and sST2 Levels on the Prognostication of Long-Term Outcomes in Patients with Coronary Artery Disease. Int J Mol Sci. 2022 Apr 13;23(8):4292.
  9. Yeh KH, Hsu LA, Juang JJ, Chiang FT, Teng MS, Tzeng IS, Wu S, Lin JF, Ko YL. Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery disease. Tzu Chi Med J. 2022 Jan 31;34(4):423-433. doi: 10.4103/tcmj.tcmj_219_21. eCollection 2022 Oct-Dec.
  10. Teng MS, Hsu LA, Wu S, Tzeng IS, Chou HH, Ko YL. Genome-wide association study revealed novel candidate gene loci associated with soluble E-selectin levels in a Taiwanese population. Atherosclerosis. 2021 Oct 15;337:18-26.
  11. Er LK, Wu S, Cheng T, Ko YL, Teng MS*. Genome-Wide Association Study on Adiponectin-Mediated Suppression of HDL-C Levels in Taiwanese Individuals Identifies Functional Haplotypes in CDH13. Genes (Basel). 2021 Oct 7;12(10):1582.
  12. Teng MS, Wu S, Hsu LA, Chou HH, Ko YL. Pleiotropic Effects of Functional MUC1 Variants on Cardiometabolic, Renal, and Hematological Traits in the Taiwanese Population. Int J Mol Sci. 2021 Sep 30;22(19):10641.
  13. Liao YH, Er LK, Wu S, Ko YL, Teng MS*. Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies. Genes (Basel). 2021 Jan 22;12(2):148.
  14. Hsu LA, Chou HH, Teng MS, Wu S, Ko YL. Circulating chemerin levels are determined through circulating platelet counts in nondiabetic Taiwanese people: A bidirectional Mendelian randomization study. Atherosclerosis. 2021 Mar;320:61-69.
  15. Chou HH, Teng MS, Hsu LA, Er LK, Wu S, Ko YL. Circulating chemerin level is associated with metabolic, biochemical and haematological parameters-A population-based study. Clin Endocrinol (Oxf). 2021 Jun;94(6):927-939.
  16. Yeh KH, Chang YT, Juang JJ, Chiang FT, Teng MS, Wu S, Lin JF, Ko YL. Combined corrected QT interval and growth differentiation factor-15 level has synergistic predictive value for long-term outcome of angiographically confirmed coronary artery disease. Int J Clin Pract. 2021 Jul;75(7):e14180.
  17. Liao YH, Teng MS, Juang JJ, Chiang FT, Er LK, Wu S, Ko YL. Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease. Mol Genet Genomic Med. 2020 Sep;8(9):e1370.
  18. Hsu HT, Yue CT, Teng MS, Tzeng IS, Li TC, Tai PA, Huang KF, Chen CY, Ko YL. Immuohistochemical score of matrix metalloproteinase-1 may indicate the severity of symptomatic cervical and lumbar disc degeneration. Spine J. 2020 Jan;20(1):124-137.
  19. Duan DM, Jhang JY, Wu S, Teng MS, Hsu LA, Ko YL. Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women. Mol Genet Genomic Med. 2020 Mar;8(3):e1113.
  20. Teng MS, Wu S, Hsu LA, Tzeng IS, Chou HH, Su CW, Ko YL. Pleiotropic association of LIPC variants with lipid and urinary 8-hydroxy deoxyguanosine levels in a Taiwanese population. Lipids Health Dis. 2019 May 10;18(1):111.
  21. Er LK, Hsu LA, Juang JJ, Chiang FT, Teng MS, Tzeng IS, Wu S, Lin JF, Ko YL. Circulating Chemerin Levels, but not the RARRES2 Polymorphisms, Predict the Long-Term Outcome of Angiographically Confirmed Coronary Artery Disease. Int J Mol Sci. 2019 Mar 7;20(5). pii: E1174.
  22. Teng MS#, Wu S#, Er LK, Hsu LA, Chou HH, Ko YL. LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels. Diabetol Metab Syndr. 2018 Nov 6;10:79.
  23. Er LK, Teng MS, Wu S, Hsu LA, Tzeng IS, Cheng CF, Chang HI, Chou HH, Ko YL.  Combined effect of acid-sensing ion channel 3 and transient receptor potential vanilloid 1 gene polymorphisms on blood pressure variations in Taiwanese. Ci Ji Yi Xue Za Zhi. 2018 Jan-Mar;30(1):29-36..
  24. Teng MS, Hsu LA, Juan SH, Lin WC, Lee MC, Su CW, Wu S*, Ko YL*. A GDF15 3′ UTR variant, rs1054564, results in allele-specific translational repression of GDF15 by hsa-miR-1233-3p. PLoS One. 2017 Aug 14;12(8):e0183187.
  25. Wu S*, Teng MS*, Er LK, Hsiao WY, Hsu LA, Yeh CH, Lin JF, Lin YY, Su CW, Ko YL*. Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese. PLoS One. 2017 Jan 17;12(1):e0169516. (Equal contribution for first author)
  26. Teng MS, Wu S, Hsu LA, Chou HH, Ko YL. Differential associations between CDH13 genotypes, adiponectin levels, and circulating levels of cellular adhesive molecules. Mediators Inflamm. 2015;2015:635751.
  27. Teng MS, Hsu LA, Wu S, Sun YC, Juan SH, Ko YL. Association of CDH13 Genotypes/Haplotypes with Circulating Adiponectin Levels, Metabolic Syndrome, and Related Metabolic Phenotypes: The Role of the Suppression Effect. PLoS One. 2015 Apr 13;10(4):e0122664.