瀏覽人氣：1,186

郭展延 副研究員

最高學歷：東海大學生命科學系生物醫學組博士

研究領域：癌症生物學、幹細胞生物學、疾病動物模式

分機：7661

電子信箱：xdf03121@tzuchi.com.tw

https://orcid.org/0000-0002-5702-5730

  • 大黃酚抑制HBx蛋白質誘導肝臟纖維化的分子作用機制。
  • VHL抑癌基因突變在腎臟癌中所扮演的角色。

1.台北慈濟醫院:

鄭敬楓副院長、藍冑進醫師、蕭仲凱醫師、傅鍔醫師、許博智醫師、宋旻怡醫師、謝伯駿醫師、李昌狄醫師、林亞萱醫師、蔡燿州醫師、余俊賢醫師、邱佳儀醫師、侯沂錚營養師。

2.院外合作機構：

吳漢忠主任(中央研究院)、黃聰龍特聘教授/葉儀君助理教授(長庚大學)、葉月嬌教授(南華大學)、蘇立仁副教授/許藝瓊副教授(中央大學)、孫珞醫師/曾含芳醫師(台中榮總)、邱依琇助理教授(高雄醫學大學)、黃啟瑞博士(台東大學)、黃瑟德主任/黃俊諺助理研究員(義大醫院)。

3.國際合作機構：

  1. Dr. Edmund K. Waller (Professor, Winship Cancer Institute of Emory University)
  2. B. Ya-Wen Chen (Assistant Professor, Icahn School of Medicine at Mount Sinai)
  3. Dr. Inga Wang (Associated Professor, University of Wisconsin-Milwaukee)

SCI論文

  1. Yu-Ning Teng, Ming-Chang Kao, Shih-Ya Huang, Tian-Shung Wu, Tsui-Er Lee, Chan-Yen Kuo*, Chin-Chuan Hung*. Novel application of rhein and its prodrug diacerein for reversing cancer-related multidrug resistance through the dual inhibition of P-glycoprotein efflux and STAT3-mediated P-glycoprotein expression. Biomedicine & Pharmacotherapy. 2022. 150, 112995.
  2. Chih-Hung Lin, Jiunn-Sheng Wu, Po-Chun Hsieh, Valeria Chiu, Chou-Chin Lan, and Chan-Yen Kuo*. Wild Bitter Melon Extract Abrogates Hypoxia-Induced Cell Death via the Regulation of Ferroptosis, ER Stress, and Apoptosis in Microglial BV2 Cells. Evidence-Based Complementary and Alternative Medicine. 2022, Article ID 1072600.
  3. Chan-Yen Kuo†, Tsu-Yi Chen†, Pei-Hsiu Kao, Winifred Huang, Chun-Ruei Cho, Ya-Syuan Lai, Giou-Teng Yiang and Chung-Feng Kao*. Genetic Pathways and Functional Subnetworks for the Complex Nature of Bipolar Disorder in Genome-Wide Association Study. 2021. Front. Mol. Neurosci., 22.
  4. Chih-Hung Lin, Han-Fang Tseng, Po-Chun Hsieh, Valeria Chiu, Ting-Yun Lin, Chou-Chin Lan, I-Shiang Tzeng, Huan-Nung Chao, Chia-Chen Hsu, and Chan-Yen Kuo*. Nephroprotective Role of Chrysophanol in Hypoxia/ Reoxygenation-Induced Renal Cell Damage via Apoptosis, ER Stress, and Ferroptosis. 2021. Biomedicines. 9, 1283.
  5. Chan-Yen Kuo*, Tzu-Hsien Yang, Pei-Fang Tsai, and Chun-Hsien Yu*. Role of the Inflammatory Response of Raw 264.7 Cells in the Metastasis of Novel Cancer Stem-Like Cells. 2021. Medicina. 57 (8), 778.
  6. Geng-Ruei Chang #, Chan-Yen Kuo#, Ming-Yang Tsai, Wei-Li Lin, Tzu-Chun Lin, Huei-Jyuan Liao, Chung-Hung Chen*, and Yu-Chen Wang*. Anti-Cancer Effects of Zotarolimus Combined with 5-Fluorouracil Treatment in HCT-116 Colorectal Cancer-Bearing BALB/c Nude Mice. 2021. Molecules. 26(15):4683.
  7. Chan-Yen Kuo*, Valeria Chiu, Po-Chun Hsieh, Tien Hsu, and Ting-Yun Lin. Loss of Function of von Hippel-Lindau Trigger Lipocalin 2-Dependent Inflammatory Responses in Cultured and Primary Renal Tubular Cells. 2021. Oxidative Medicine and Cellular Longevity. Article ID 5571638.
  8. Chang-Hsun Ho, Jen-Hsuan Huang, Maw-ShengSun, I-Shiang Tzeng, Yi-Chiung Hsu, Chan-Yen Kuo*. Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis. 2021. Evidence-Based Complementary and Alternative Medicine. Article ID 6671129.
  9. Cheng-Lin Tsai, Chou-Chin Lan, Chih-Wei Wu, Yun-Chun Wu, Chan-Yen Kuo, I-Shiang Tzeng, Pei-Shan Hsu, Chang-Ti Lee, Po-Chun Hsieh*. Acupuncture Point Stimulation Treatments Combined With Conventional Treatment in Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis. Front Med (Lausanne). 2021,8: 586900.
  10. Po-Chih Hsu, Yi-Hsuan Chen, Ching-Feng Cheng, Chan-Yen Kuo*, and Huey-Kang Sytwu*. Interleukin-6 and Interleukin-8 Regulate STAT3 Activation Migration/Invasion and EMT in Chrysophanol-Treated Oral Cancer Cell Lines. Life. 2021, 11(5), 423.
  11. Ching-Feng Wu, Ching-Yang Wu, Robin Y.-Y. Chiou,Wei-Cheng Yan, Chuen-Fu Lin, Chao-Min Wang, Po-Hsun Hou, Tzu-Chun Lin, Chan-Yen Kuo,* and Geng-Ruei Chang *. The anti-cancer effects of a zotarolimus and 5-fluorouracil combination treatment on A549 cell-derived tumors in BALB/c nude mice. International Journal of Molecular Sciences. 2021. 22, 4562.
  12. Lin Y.-H. • Wu H.-C. • Hsieh P.-C. • Tzeng I.-S. • Wu S.-Y. • Kuo C.-Y*. An Association Rule Analysis of Combined Acupoints for the Treatment of Patients with Dry Eye Disease. Complementary Medicine Research. 2021. In press.
  13. Ping-Hsun Lu, Jui-Lin Keng, Fu-Ming Tsai, Po-Hsuan Lu*, and Chan-Yen Kuo*. An Apriori Algorithm-Based Association Rule Analysis to Identify Acupoint Combinations for Treating Diabetic Gastroparesis. 2021. Evidence-Based Complementary and Alternative Medicine. Article ID 6649331.
  14. Ping-Hsun Lu, Jui-Lin Keng, Ko-Li Kuo, Yu-Fang Wang, Yu-Chih Tai*, Chan-Yen Kuo*. An Apriori Algorithm-Based Association Rule Analysis to Identify Herb Combinations for Treating Uremic Pruritus Using Chinese Herbal Bath Therapy. Evidence-Based Complementary and Alternative Medicine. Article ID 8165296 2020.
  15. Hou YC, Lai CW, Cheng CF, Lin YY, Hsieh TH, Hui Wu J, Tzeng IS*, Kuo CY*. Effects of prebiotic consumption on serum intestinal fatty acid-binding protein levels in patients with diabetes: A case-control study. 2020. J Clin Lab Anal. e23490.
  16. Shih-Hsing Yang, Mei-Chen Yang, Yao-Kuang Wu, Chih-Wei Wu, Po-Chun Hsieh, Chan-Yen Kuo, I-Shiang Tzeng, Chou-Chin Lan*.Poor Work Efficiency is Associated with Poor Exercise Capacity and Health-Related Quality of Life in Patients with Chronic Obstructive Pulmonary Disease. Int J Chron Obstruct Pulmon Dis. 2020.16:245-256.
  17. Semon Wu, I-Chieh Tseng, Wen-Cheng Huang, Cheng-Wen Su, Yu-Heng Lai, Che Lin, Alan Yueh-Luen Lee, Chan-Yen Kuo, Li-Yu Su, Ming-Cheng Lee, Te-Cheng Hsu, Chun-Hsien Yu. Establishment of an Immunocompetent Metastasis Rat Model with Hepatocyte Cancer Stem Cells. 2020. Cancers. 12 (12):3721.
  18. Hou YC, Feng HC, Tzeng IS, Kuo CY, Cheng CF, Wu JH, Yang SH. Dietary Patterns and the Risk of Prediabetes in Taiwan: A Cross-Sectional Study. Nutrients. 2020. 12(11): E3322.
  19. Kung WM, Lin CC, Kuo CY, Juin YC, Wu PC, Lin MS. Wild Bitter Melon Exerts Anti-Inflammatory Effects by Upregulating Injury-Attenuated CISD2 Expression following Spinal Cord Injury. Behavioural Neurology. Volume 2020. Article ID 1080521.
  20. Wang CH, Wang LK, Wu CC, Chen ML, Kuo CY, Shyu RY, Tsai FM. Cathepsin V Mediates the Tazarotene-induced Gene 1-induced Reduction in Invasion in Colorectal Cancer Cells. Cell Biochemistry and Biophysics. 2020. 78:483–494.
  21. Chung PC, Hsieh PC, Lan CC, Hsu PC, Sung MY, Lin YH, Tzeng IS, Chiu V, Cheng CF, Kuo CY*. Role of Chrysophanol in Epithelial-Mesenchymal Transition in Oral Cancer Cell Lines via a Wnt-3-Dependent Pathway. Evidence-Based Complementary and Alternative Medicine. Volume 2020. Article ID 8373715.
  22. Chan-Yen Kuo* Valeria Chiu, Po-ChunHsieh, Chun-Yen Huang, S. Joseph Huange, I-ShiangTzeng, Fu-MingTsai, Mao-Liang Chen, Chien-Ting Liu, Yi-Ru Chen. Chrysophanol attenuates hepatitis B virus X protein-induced hepaticstellate cellfibrosis by regulating endoplasmic reticulum stress and ferroptosis. Journal of Pharmacological Sciences. 2020. 144 (3): 172-182.
  23. Chien-Cheng Chen, Tzyy-Yue Wong, Tzu-Yun Chin, Wen-Hsien Lee, Chan-Yen Kuo*, Yi Chiung Hsu*. Systems Biology Approaches to Explore Cyclic Stretching in Cardiac Cell Physiology. Aging. 2020. 12(16):16035-16045.
  24. Jiunn-Sheng Wu #, Valeria Chiu#, Chou-Chin Lan, Chan-Yen Kuo*, Po-Chun Hsieh*. Chrysophanol mediates hepatic stellate cell apoptosis by regulating reactive oxygen species accumulation and expression of caspase-3, JNK, p38 MAPK, α-SMA, and CTGF. Evidence-Based Complementary and Alternative Medicine. Volume 2020. Article ID 8426051.
  25. Po-Chih Hsu, Ching-Feng Cheng, Po-Chun Hsieh, Yi-Hsuan Chen, Chan-Yen Kuo*, and Huey-Kang Sytwu*. Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine. Volume 2020. Article ID 5867064.
  26. Po-Chun Hsieh, Chu-Fang Cheng, Chih-Wei Wu, I-Shiang Tzeng, Chan-Yen Kuo, Pei-Shan Hsu, Chang-Ti Lee, Min-Chien Yu, and Chou-Chin Lan*. Combination of acupoints in treating patients with chronic obstructive pulmonary disease: An Apriori algorithm-based association rule analysis. Evidence-Based Complementary and Alternative Medicine. Volume 2020, Article ID 8165296.
  27. Huang JH, Lan CC, Hsu YT, Tsai CL, Tzeng IS, Wang P, Kuo CY *, Hsieh PC *, Oridonin attenuates lipopolysaccharide-induced ROS accumulation in HK-2 cells and inhibits RAW 264.7 cell chemotaxis. Evidence-Based Complementary and Alternative Medicine. Volume 2020, Article ID 9724520 .
  28. Lin CH, Lan CC, Chiu Valeria, Hsieh PC *, Kuo CY*, Lee CT*. Danshensu attenuates hypoxia-induced ROS production and iNOS expression in RAW 264.7 cells. Current Topics in Nutraceutical Research 2020; 18:1-7.
  29. Kuo CY, Kung WM, Lin MS. Neuronal CISD2 plays a minor anti-inflammatory role in LPS-stimulated neuron-like SH-SY5Y cells. Neurol Sci. 2019 26; 408:116549.
  30. Sun MH, Liang CY, Hsieh PC *, Kuo CY*, Danshensu Rescues Ischemia/Reperfusion Caused Human Hepatocyte Death, Current Topics in Nutraceutical Research, 2019;17(2):1-5
  31. Yung‐Hsiang Yeh, Chun‐Ya Liang, Mao‐Liang Chen, Fu‐Ming Tsai, Yi‐Ying Lin, Ming‐Cheng Lee, Jiunn‐Sheng Wu*, Chan‐Yen Kuo*.Apoptotic effects of hsian‐tsao (Mesona procumbens Hemsley) on hepatic stellate cells mediated by reactive oxygen species and ERK, JNK, and caspase‐3 pathways. Food Sci Nutr. 2019;7:1891–1898. (IF=1.747, Ranking = 67/135, Food Science & Technology)
  32. Hsu CP, Lin CH, Kuo CY*. Endothelial-cell inflammation and damage by reactive oxygen species are prevented by propofol via ABCA1-mediated cholesterol efflux. Int. J. Med. Sci., 2018; 15(10): 978-985. (IF=2.284, Ranking = 46/154, MEDICINE).
  33. Kuo CY, Lin CH, Hsu T*., VHL inactivation in precancerous kidney cells induces inflammatory response via ER stress-activated IRE1 signaling. Cancer Research. 2017;77(13):3406-3416.
  34. Shao YC#, Liou JC#, Kuo CY#, Tsai YS, Lin EC, Hsieh CJ, Lin SP, Chen BY*., UVB promotes the initiation of uveitic inflammatory injury in vivo and is attenuated by UV-blocking protection. Mol. Vis. 2017;23:219-227.
  35. Chen CC, Kuo CY, Chen RF*., Role of CAPE on cardiomyocyte protection via connexin 43 regulation under hypoxia. Int J Med Sci. 2016; 13(10):754-758.
  36. Kuo CY, Lee YL*, Hwang TL*., Mitochondrial Lon protease controls ROS-dependent apoptosis in cardiomyocyte under hypoxia . Mitochondrion. 2015;23:7-16.
  37. Kao TY, Chiu YC, Fang WC, Cheng CW, Kuo CY, Juan HF, Wu SH, Lee AY*., Mitochondrial Lon regulates apoptosis through the association with Hsp60-mtHsp70 complex. Cell Death Dis. 2015; 6:e1642.
  38. Kuo LM#, Kuo CY#, Lin CY, Hung MF, Shen JJ, Hwang TL*., Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells. Molecules. 2014;19(3):3327-44.
  39. Cheng AN, Jiang SS, Fan CC, Lo YK, Kuo CY, Chen CH, Liu YL, Lee CC, Chen WS, Huang TS, Wang TY, Lee AY*., Increased Cdc7 expression is a marker of oral squamous cell carcinoma and overexpression of Cdc7 contributes to the resistance to DNA-damaging agents. Cancer Letter. 2013;337(2):218-25.
  40. Yang SC, Chung PJ, Ho CM, Kuo CY, Hung MF, Huang YT, Chang WY, Chang YW, Chan KH, and Hwang TL*., Propofol Inhibits Superoxide Production, Elastase Release, and chemotaxis in Formyl Peptide-Activated Human Neutrophils by Blocking FPR1. Journal of Immunology. 2013;190(12):6511-9.
  41. Cheng CW#, Kuo CY#, Fan CC#, Fang WC, Jiang SS, Lo YK, Wang TY, Kao MC and Lee Alan YL*., Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species. Cell Death & Disease. 2013;4:e681.
  42. Kuo CY, Chou TY, Chen CM, Hwang GY*, Hwang TL*., Hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis. Virus Research. 2013;175(1):20-9.
  43. Kuo CY, Tsai JI, Chou TY, Hung MJ, Wu CC, Hsu SL, Hwang GY*., Apoptosis

induced by hepatitis B virus X protein in a CCL13-HBx stable cell line. Oncol. Rep. 2012;28(1):127-32.

  1. Lee PH, Tsai SH, Kuo L, Hwang CY, Kuo CY, Yang VC*, Chen JK*., A prototype tissue engineered blood vessel using amniotic membrane as scaffold. Acta. Biomater. 2012;8(9):3342-8. (NSC96-2745-B-029-001-URD).
  2. Ho HC, Chang HC, Ting CT, Kuo CY*, Yang VC*., Caffeic acid phenethyl ester inhibits proliferation, migration, and induces apoptosis in platelet-derived growth factor (PDGF)-stimulated human coronary smooth muscle cells. J. Vasc. Res. 2012;49(1):24-32.
  3. Kuo CY, Lin YC, Yang JJ, Yang VC*., Interaction abolishment between mutant caveolin-1 Δ61-101 and ABCA1 reduces HDL-mediated cellular cholesterol efflux. Biochem. Biophys. Res. Commun. 2011;414(2):337-43. (NSC97-2311-B-029-003-MY3).
  4. Ho HC, Hsu SL, Ting CT, Kuo CY*, Yang VC*., Caffeic acid phenethyl ester inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using a local delivery system. Cellular and Molecular Biology. 2009;55, OL1161-67.
  5. Lin YC, Lin CH, Kuo CY, and Yang VC*., ABCA1 modulates the oligomerization and Golgi exit of caveolin-1 during HDL-mediated cholesterol efflux in aortic endothelial cells. Biochem. Biophys. Res. Commun. 2009; 382(1):189-95. (NSC96-2311-B-029-003).
  6. Kuo CY, Wang JC, Hsu SL, Hwang GY*., Functional characterization of hepatitis B virus X protein based on the inhibition of tumorigenesis in nude mice injected with CCL13-HBx cells. Intervirology. 2008;253-60.
  7. Kuo CY, Wu CC, Hsu SL, Hwang GY*., HBx inhibits the growth of CL13-HBX-stable cells via the GSK-3ß-catenin cascade. Intervirology. 2008;51; 130-36.
  8. Kuo CY, Wang JC, Wu CC, Hsu SL, Hwang GY*., Effects of Hepatitis B virus X protein (HBx) on cell-growth inhibition in a CCL13-HBx stable cell line. Intervirology. 2008;51:26-32.